Response of selected node
Map summary and publication info
* Nodes are considered regulated if the confidence interval of the controls does not intersect the confidence interval of the model. A sum(CI) can be calculated as the sum of distances between the two confidence intervals at each measured concentration. This measure can give an indication of direction and magnitude of regulation but it does not equate to significance.
About this app
This app allows exploring zebrafish toxicogenomic fingerprints (with the whole transcriptome shown on the map) by:
- Selecting exposure conditions (substance, concentration and time point (hpe = hours post exposure, please note that exposure start points may differ and are described in the respective publications) to view the SOM plot specific to the respective condition.
- Selecting nodes on the fingerprint by either clicking on them, selecting them directly or via a gene through the node and gene selection dropdown menus in the sidebar. When a selection has been made, a plot on the right will display the fitted model of the node, usually across mutiple conditions, and the table at the bottom displays information about the genes contained on the node.
This app was initially created as a supplement to Schüttler et al. (2019): "Map and model—moving from observation to prediction in toxicogenomics". The current version contains additional datasets and models. Future updates are planned.
For questions, please contact Paul Michaelis (email@example.com)
Version 4.0.1 - Copyright (C) 2018-2021 Helmholtz Centre for Environmental Research - UFZ
This program is free software: you can redistribute it and/or modify it under the terms of the GNU General Public License as published by the Free Software Foundation, either version 3 of the License or (at your option) any later version.
This program is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the GNU General Public License for more details (https://www.gnu.org/licenses/).